Awesome, so far nothing forced; it's just testing in the background, then..?
I've waited on changing the PSU because I wanted to try to isolate if it was a storage/driver/windows issue first. No luck with that, unfortunately. 
However! I can give it a try. Let me summarise what I've done and where I'm at so far.
(Assume all Drivers/BIOS are latest with the exception of IDE/ATAPI drivers, as mentioned below.)
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Currently, I've had momentary stutters/stops/audio tears.
I seem to have completely stopped the audio tears by switching from the usual AMD IDE/ATAPI drivers to Windows Generics.
This is awesome!
However, it is replaced by occasional 'pauses' where things lock up. I tried solving that by disabling prefetch/superfetch.
No dice, and I am worried about trying so many 'small' fixes and forgetting what to re-enable.
The latency is not the only problem as my computer still crashes once in 1-10 days, seemingly at random.
And I would post in the BSOD forum, but not only is there no bluesceen, I think it might simply be my drivers/drives locking up or a PSU halt that causes the computer to lock and instantly reset in panic.
I feel so close to finding out what it is, but also so far!
So, alas, I can't just uninstall LatencyMon and have peace of mind, but maybe I'm closer then I think, fingers crossed... 
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This might be a long one, I'm assuming it's okay to post progress here when I've tried something new?
And thanks, not just for the reply, but the good humour and support. Both are always appreciated. 